Preferred Specimen(s) 1 mL Serum
Transport Container Plastic screw cap vial
Transport Temperature Frozen
Reject Criteria Hemolyzed
Methodology Chemiluminescence Assay
Clinical Significance Maternal serum PAPP-A assessment between 11 and 14 weeks of pregnancy is reported to have significant utility in screening & Down syndrome and other chromosomal abnormalities. A combination of maternal age related risk, Free â-HCG & fetal nuchal translucency (NT) measurements might substantially increase the efficiency of prenatal screening compared to second trimester screening; using this approach, various investigators have reported detection rate for Down syndrome of 85 to 90 percent at a five percent false positive rate.