Preferred Specimen(s)
- 1mL Serum,
- Heparinized plasma,
- Body fluids (Pleural fluid, Peritoneal fluid, CSF)
Transport Container Plastic screw-cap vial
Transport Temperature Refrigerated, Stable for 7 days
Methodology Spectrophotometry
Clinical Significance ADA is an enzyme catalyzing the deamination reaction from adenosine to inosine. The enzyme is widely distributed in human tissues, especially high in T Iymphocytes.
Elevated serum ADA activity has been observed in patients with acute hepatitis, alcoholic hepatic fibrosis, chronic active hepatitis, liver cirrhosis, viral hepatitis and hepatoma. Increased ADA activity was also observed in patients with tuberculosis effusions. Deamination of ADA activity in patient serum may add unique values to the diagnosis of liver diseases in combination with ALT or gamma-GT (GGT) tests. ADA assay may also be useful in the diagnosis of tuberculosis.