Preferred Specimen(s): 1 mL serum
Minimum Volume: 0.2 mL
Transport Temperature: Room temperature
Specimen Stability:
- Room temperature 4 days
- Refrigerated 7 days
- Frozen 30 days
Reject Criteria: Gross hemolysis
· Gross lipemia
· Icteric
Methodology: Immunoassay (IA)
Reference Range(s)
| Value | Interpretation |
| ≤0.90 | Negative |
| 0.91-1.09 | Equivocal |
| ≥1.10 | Positive |
Clinical Significance: Primary infection by EBV causes infectious mononucleosis, usually a self-limiting disease in children and young adults. Infection with EBV can cause lymphoproliferative disorders including tumors. VCA-IgG is typically detectable at clinical presentation, and persists for life. Absence of VCA-IgG usually indicates the patient is susceptible to EBV infection.