Preferred Specimen(s) 1.0 mL serum
Transport Container Plastic screw-cap vial
Transport Temperature
- Refrigerated 3 days,
- -20oC Long term
Reject Criteria
- Gross hemolysis
- Plasma
Methodology ELISA
Clinical Significance Phospholipid autoantibodies specific to phosphatidylinositol(PI), phosphatidylglycerol(PG),phosphatidylserine(PS),phosphatidylethanolamine(PE),phosphatidylcholine(PC),phosphatidic acid(PA), cardiolipin(CL) and sphingomyelin are found in hematolgic autoimmune diseases, especially antiphospholipid syndrome(APS) and systemic lupus erythematosus(SLE). APS is characterized by arterial and venous thrombosis, thrombocytopenia, and recurrent fetal loss; thrombosis, thrombocytopenia and hemolytic anemia also occur in SLE and are associated with the presence of phospholipid autoantibodies. Women with infertility showing spontaneous abortion or in vitro fertilization failure demonstrate PI autoantibodies in 25% of cases.