Prothrombin (Factor II) A Mutation Analysis

Preferred Specimen(s) 5 mL whole blood

Transport Container EDTA (lavender-top)

Transport Temperature Room temperature

Reject Criteria Received frozen

Methodology Polymerase Chain Reaction, Oligonucleotide Ligation Assay, Fluorescent Microspheres

Clinical Significance Factor II Mutation (G20210A) is one of the most common causes of venous thrombosis. 2.3% of the general population is heterozygous in contrast with 6.2% of patients with venous thrombosis and 18% with familial venous thrombosis. Other risk factors compound the risk for venous thrombosis.