Includes Protein-C Functional, Protein-S Functional, APC-R, Antithrombin III, ANA ELISA, Anti DsDNA,
Factor V Leiden, Complement C3, Complement C4, Lupus Anti Coagulant (screening), Anti Cardiolipin – IgG & Anti Cardiolipin IgM
Preferred Specimen(s) For Specimen requirements see individual Tests listed under Test Components.
Transport Container Plastic screw cap vial
Transport Temperature See individual tests for transport temperature
Reject Criteria
- Hemolyzed,
- lipemic,
- leaked &
- QNS specimens
Methodology
- Chromogenic; Enzyme Immunoassay Invader Assay/Signal Amplification Clotting Assay
- Fluorescence polarizaton Immunoassay Clot Detection
Clinical Significance Decreased antithrombin III activity, protein C activity, free protein S, and the presence of a factor V (Leiden) and/or factor II 20210G>A mutation each contribute to an increased risk of hereditary thrombophilia. Approximately 10% of factor V (Leiden) heterozygotes also carry the prothrombin 20210G>A mutation. Likewise, protein C and/or S deficiency have been reported with factor V (Leiden) mutation. Since venous thrombosis is a multifactorial disorder, presence of a second risk factor further increases the thrombotic risk.